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Marble Details - Confirmation
Marble Details - Confirmation
Confirmation of CD86 downregulation in hematopoietic stem and progenitor cells upon inflammation
Confirmation of CD86 downregulation in hematopoietic stem and progenitor cells upon inflammation
Date of publication:
29 Oct 2025
Version 1
Authors
Authors
Pablo Hernández-Malmierca [1,2,3,*]; Andreas Trumpp [1,2,4]; Simon Haas [1,2,4,5,6,7,#]
Authors
Authors
Linked article information
Linked article information
Authors Affiliation
Authors Affiliation
Hematopoietic stem and progenitor cells (HSPCs) replace all blood and immune cells throughout life. In young and adult mammals, HSPCs reside in the bone marrow. Environmental signals regulate HSPC behavior, enabling context-dependent responses to challenges. Hence, they respond to physiological demands through cell cycle or lineage-specific adaptations. Surface molecules are the primary mechanism for cellular communication, either with environmental cues or with other cells. Here, we confirm constitutive CD86 expression in murine HSPCs and its downregulation upon inflammation. In addition, we demonstrate the same CD86 expression pattern on purified HSCs.
Keywords
Acute inflammation; CD86; Hematopoietic stem cells; Progenitor cells
Are you testing a hypothesis that appears in the article?
Are methods the same?
Are materials the same?
Does the result confirm the findings in the article?
Abstract
Hematopoietic stem and progenitor cells (HSPCs) replace all blood and immune cells throughout life. In young and adult mammals, HSPCs reside in the bone marrow. Environmental signals regulate HSPC behavior, enabling context-dependent responses to challenges. Hence, they respond to physiological demands through cell cycle or lineage-specific adaptations. Surface molecules are the primary mechanism for cellular communication, either with environmental cues or with other cells. Here, we confirm constitutive CD86 expression in murine HSPCs and its downregulation upon inflammation. In addition, we demonstrate the same CD86 expression pattern on purified HSCs.
Keywords
Acute inflammation; CD86; Hematopoietic stem cells; Progenitor cells
Are you testing a hypothesis that appears in the article?
Are methods the same?
Are materials the same?
Does the result confirm the findings in the article?
Abstract
Hematopoietic stem and progenitor cells (HSPCs) replace all blood and immune cells throughout life. In young and adult mammals, HSPCs reside in the bone marrow. Environmental signals regulate HSPC behavior, enabling context-dependent responses to challenges. Hence, they respond to physiological demands through cell cycle or lineage-specific adaptations. Surface molecules are the primary mechanism for cellular communication, either with environmental cues or with other cells. Here, we confirm constitutive CD86 expression in murine HSPCs and its downregulation upon inflammation. In addition, we demonstrate the same CD86 expression pattern on purified HSCs.
Keywords
Acute inflammation; CD86; Hematopoietic stem cells; Progenitor cells
Are you testing a hypothesis that appears in the article?
Are methods the same?
Are materials the same?
Does the result confirm the findings in the article?
Marble ID:
Marble ID:
MR0001V1
(Pending DOI assignment)
(Pending DOI assignment)
Status:
Status:
Accepted with changes
Accepted with changes
Linked article information
Title
Authors
Esplin BL, Shimazu T, Welner RS, Garrett KP, Nie L, Zhang Q, Humphrey MB, Yang Q, Borghesi LA, Kincade PW
Esplin BL, Shimazu T, Welner RS, Garrett KP, Nie L, Zhang Q, Humphrey MB, Yang Q, Borghesi LA, Kincade PW
DOI
Related figures
Figure(s) 6
Figure(s) 6
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Copyright
© 2025, Hernández-Malmierca et al.
This Marble is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
Copyright Research Agora Collective SL, 2025
Copyright Research Agora Collective SL, 2025
Copyright Research Agora Collective SL, 2025
Copyright
© 2025, Hernández-Malmierca et al.
This Marble is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.